Ku E, et al. - Researchers herein focused on the association of blood pressure (BP) trajectories during young adulthood with subsequent decline in kidney function. They noted that during young adulthood, increasing systolic (SBP) and diastolic BP (DBP) were related to a higher rate of subsequent kidney function decline. This link was independent of BP measured at the beginning of estimated glomerular filtration rate assessment.

• Researchers carried out an observational cohort study.
• Study participants included a total of 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years.
• BP slope during the first 10 years of participation in CARDIA, derived from linear mixed models incorporating all repeated BP measures, was included as predictor.
• Outcome included decline in estimated glomerular filtration rate (eGFR) during the interval between years 10 and 20 of CARDIA participation using cystatin C measured at years 10, 15, and 20.

• As per data, mean age of CARDIA participants at year 0 was 25.1 years, 56% were women, and 53% were white.
• Researchers found that every 10–mm Hg higher level of systolic (SBP) and diastolic BP (DBP) in year 10 was related to change in eGFR of -0.09 (95% CI, -0.13 to -0.06) and -0.07 (95% CI, -0.12 to -0.03) mL/min/1.73 m² per year, respectively.
• They noted that after adjustment for comorbid conditions and SBP at year 10, every 10–mm Hg increase in SBP slope between years 0 and 10 was related to a subsequent -0.52 (95% CI, -1.02 to -0.03) mL/min/1.73 m² per year change in kidney function.
• Similarly, findings demonstrated that every 10–mm Hg increase in DBP slope between years 0 and 10 was associated with a subsequent change in kidney function of -0.65 (95% CI, -1.23 to -0.07) mL/min/1.73 m² per year, after adjustment for comorbid conditions and DBP in year 10.