Shih CW, et al. - In this secondary analysis of the DIETFITS weight loss trial, researchers primarily assessed the links between changes in percentage of dietary saturated fatty acid intake (%SFA) and changes in low-density lipoproteins, high-density lipoproteins, and triglyceride concentrations for those following a healthy low-carbohydrate (HLC) diet. They also assessed these links exclusively for HLC dieters who had the highest 12-month increases in %SFA. They randomized 609 generally healthy adults (aged 18–50 years) with body mass indices of 28–40 kg/m² to a healthy low-fat (HLF) or HLC diet for 12 months. They assessed the link between 12-month change in %SFA and blood lipids by using linear regression, both without and with adjustment for potential confounders in this current analysis, in 208 HLC participants with complete diet and blood lipid data. According to findings, improvement in the overall lipid profile of individuals on a low-carbohydrate weight-loss diet who increased their percentage intake of dietary saturated fat could be achieved if they focus on a high-quality diet and exercise lower intakes of both calories and refined carbohydrates.