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Changes in aqueous and vitreous inflammatory cytokine levels in neovascular age‐related macular degeneration: A systematic review and meta‐analysis

Acta Ophthalmologica Mar 18, 2021

Minaker SA, Mason RH, Luna GL, et al. - Since inflammatory cytokines are involved in the pathogenesis of neovascular age‐related macular degeneration (nAMD) and have been shown to be valuable as diagnostic and predictive biomarkers, researchers conducted this systematic review and meta‐analysis to quantitatively summarize data related to inflammatory cytokines in nAMD. Studies with data on aqueous or vitreous cytokine concentrations in patients with nAMD were included. Data were obtained from 95 studies that encompassed 3,105 study eyes with nAMD and 1,209 control eyes. Among the 4,314 eyes in 95 studies, aqueous concentrations of MCP‐1, MIG, TGF‐β and VEGF were significantly higher in patients with nAMD vs healthy controls. The study identifies multiple candidate cytokines other than VEGF that are involved in nAMD and adds to the existing literature. This will aid in focusing translational research in nAMD on biomarkers and therapeutic targets.

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