Yum HR, et al. - In this retrospective, observational case series, researchers reported a longitudinal change of ocular parameters in children with large cup-to-disc ratio (CDR) and interocular CDR asymmetry. The sample consisted of 160 children (160 eyes), mean age 7.14 ± 2.42 years, with large CDR who visited a tertiary eye center from January 2010 to June 2016. Over the study period, no significant differences were found in the changes of optic nerve head analysis, and retinal nerve fiber layer, and macular ganglion cell-inner plexiform layer thicknesses in children with large CDR, or those with interocular CDR asymmetry. The findings will aid in the development of guidelines for the management of children with large CDR and interocular CDR asymmetry.