Cervical ripening in prolonged pregnancies by silicone double balloon catheter vs vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial
PLoS Medicine Mar 13, 2021
Diguisto C, Le Gouge A, Arthuis C, et al. - Researchers conducted this trial with the aim to determine if in prolonged pregnancies, the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour could aid in lowering the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). This multicentre, superiority, open-label, parallel-group, randomised controlled trial was conducted in 15 French maternity units including women with singleton pregnancies, a vertex presentation, ≥ 41+0 and ≤ 42+0 weeks’ gestation, a Bishop score < 6, intact membranes, and no history of cesarean delivery for whom induction of labour. A total of 1,220 women were randomised in a 1:1 ratio to either mechanical cervical ripening with a Cook Cervical Ripening Balloon or pharmacological cervical ripening by a Propess vaginal pessary serving as a prostaglandin E2 slow-release system. Outcomes revealed that the rates of cesarean deliveries for nonreassuring fetal status did not differ between mechanical ripening with a silicone double balloon catheter and pharmacological cervical ripening with a pessary for the slow release of dinoprostone.
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