Cervical ripening in prolonged pregnancies by silicone double balloon catheter vs vaginal dinoprostone slow release system: The MAGPOP randomized controlled trial
PLoS Medicine Feb 17, 2021
Diguisto C, Le Gouge A, Arthuis C, et al. - When pregnancies reach 41 weeks of gestation, there may be necessity for induction of labor. As cervical ripening is recommended prior to oxytocin administration in cases with unfavorable cervix to enhance the chances of vaginal delivery, researchers conducted this trial examining if the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labor in prolonged pregnancies decreases the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). From January 2017 to December 2018, they randomized 1,220 women in a 1:1 ratio; 610 women were allocated to a silicone double balloon catheter, and 610 to the Propess vaginal pessary for the slow release of dinoprostone. Outcomes did not support the superiority of cervical ripening with a silicone double-balloon catheter over cervical ripening with a vaginal dinoprostone slow-release system in terms of lowering the rate of cesarean for nonreassuring fetal heart rate and overall maternal and neonatal morbidity.
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