Central adiposity in relation to risk of liver cancer in Chinese adults: A prospective study of 0.5 million people
International Journal of Cancer Feb 19, 2019
Pang Y, et al. - Researchers examined how central adiposity impacts liver cancer risk in a relatively lean Chinese population of 512,713 adults aged 30-79 years from 10 diverse areas from the prospective China Kadoorie Biobank. They reported 2,847 incident cases of liver cancer over 10 years follow-up. Adjusted hazard ratios (HR) were calculated excluding individuals with cancers and liver diseases at baseline and in the first 5 years of follow-up (1,049 incident liver cancer cases). Men and women had a mean waist circumference (WC) of 82.2 (standard deviation 9.8) cm and 79.1 (9.5) cm, respectively. According to the findings, central adiposity was positively related to the risk of liver cancer. The strongest correlations were shown by waist-to-hip ratio (WHR) and WC. Additional adjustment for BMI further enhanced the strength of the positive associations.
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