Cell block processing is optimal for assessing endoscopic ultrasound fine needle aspiration specimens of pancreatic mucinous cysts
Journal of Clinical Pathology Jan 26, 2020
Wong WACS, Gwiti1 P, Murigu T, et al. - For the first time, researchers systematically analyzed the cell block technique for evaluating endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) specimens from pancreatic mucinous cystic lesions (MCLs), including comparisons with three traditional methods of assessing such specimens. The prospective and retrospective arms of the study included 80 and 30 EUS-FNA specimens, respectively. The results showed that cell block preparations are as likely to distinguish mucin from pancreatic MCLs as macroscopic evaluation but are twice as likely to diagnose MCL than direct smears and fluid carcinoembryonic antigen biochemistry. They noted that, for sample collection and processing, the cell block technique is easy especially because these are identical for solid and cystic pancreatic lesions.
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