Verbeek R, et al. - Given that elevated lipoprotein(a) (Lp(a)) has been suggested to cause cardiovascular disease (CVD) mostly in patients with high low-density lipoprotein cholesterol (LDL-C) levels, researchers presumed that the risk associated with high Lp(a) levels would largely be reduced at low LDL-C levels. They tested this hypothesis by performing parallel statistical analyses in 16,654 individuals from the EPIC-Norfolk prospective population study, and in 9,448 individuals from the Copenhagen City Heart Study. They found an independent association of Lp(a) and LDL-C with CVD risk. They also noted a reduction of the risk associated with elevated Lp(a) at LDL-C levels below < 2.5 mmol/L in a primary prevention setting.