Liu X, et al. - Researchers examined participants (n=38,989) from Chinese Multicenter Longitudinal Health Management Cohorts (mean age 42 years; 62% male) without baseline cardiovascular disease (CVD) to assess the CVD risk related to various adverse lipid combinations. These subjects were followed from 2007 to 2015 to assess incident CVD. Increased CVD risk was reported in relation to low high-density lipoprotein cholesterol (HDL-C) combined with either high non–HDL-C alone or triglycerides (TG) alone, with adjusted hazard ratios of 1.77 and 2.08 in men after multivariable adjustment. Greater risk of incident CVD was observed in participants who are diabetic with high non–HDL-C and low HDL-C levels, and in those without diabetes with high TG and low HDL-C levels. On restricting analysis to participants with normal LDL-C levels of <3.4 mmol/L, these observed links continued to be significant. This is suggestive of the association of various combinations of out-of-range lipid profiles, other than LDL-C, with different CVD risk.