Shigdel R, et al. – In a cohort of 26,163 participants from the HUNT study, researchers examined the link between estimated cardiorespiratory fitness (eCRF) and risk of first acute myocardial infarction (AMI). Participants had a mean age of 55.7 years and did not have cardiovascular disease at baseline. A mean (range) follow-up of 13 (0.02–15.40) years (347,462 person-years) was performed among participants, which revealed documentation of 1,566 AMI events. Among women—but not in men—an inverse association of eCRF with risk of AMI event was evident. In attenuating AMI risk, a possible substantial benefit of high eCRF was suggested. Based on the findings, it is justifiable to increase focus on eCRF as a cardiovascular disease risk marker in middle-aged and older adults.