Cardiac troponin T and right ventricular systolic pressure predict cardiovascular and mortality risk in kidney transplant candidates
American Journal of Nephrology Oct 27, 2019
Firth C, Kaur T, Chakkera H, et al. - In a racially diverse cohort with significant cardiovascular (CV) disease burden presenting for kidney transplant (KTx) assessment, whether CV events and mortality could be predicted by cardiac troponin T (cTnT) was investigated. Researchers also evaluated right ventricular systolic pressure (RVSP) in predicting these outcomes. Participants were 561 patients presenting for KTx assessment from 2011 to 2013 at Mayo Clinic, Arizona. They derived a cutoff value for cTnT and RVSP, which was most related to CV events or death. The study sample included 70.6% (n = 392) White, 11.4% (n = 63) Black, 8.5% (n = 47) Native American, and 3.1% (n = 17) Asian, with mean age 53.5 ± 13.7 years. The participants were observed over a median duration of 48.0 months following KTx evaluation. Findings revealed independent predictive ability of elevated cTnT and RVSP for CV events and mortality in the cohort. Considering the value of RVSP and cTnT as markers of CV risk in KTx assessment was recommended.
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