Hou Y, Zhou Y, Hussain M, et al. - A longitudinal patient–patient network clustering methodology was developed for cardiac risk stratification in cancer patients during anticancer therapies.

• In a large longitudinal (up to 22 years’ follow-up from March 1997 to January 2019) cardio-oncology cohort of 4,632 cancer patients with 5 diagnosed cardiac outcomes (atrial fibrillation, coronary artery disease, heart failure, myocardial infarction, and stroke), four clinically relevant subgroups were identified that were statistically significantly linked with incidence of cardiac outcomes and all-cause mortality.

• Early cardiovascular care is identified to have a crucial role in improving quality of life of cancer survivors and reducing incidence of cancer therapy–related cardiac dysfunction (CTRCD) on performing longitudinal patient–patient network analyses (over 20 years’ follow-up).

• Multiple clinically relevant predictors (including Troponin T and NT-proB-type Natriuretic Peptide (NT-proBNP)) are identified to have significant association with incidence of cardiac outcomes and patients’ mortality.

• Troponin T and NT-proBNP offer actionable biomarkers for rapid risk assessment of cardiac dysfunction during cardio-oncology clinical practices.