Sanna GD, et al. - In this case-control study that included 32 patients with Alzheimer disease (AD) and 34 controls matched by age and sex, researchers focused on cardiac abnormalities in AD. All the participants were free from cardiac or systemic diseases and underwent a clinical evaluation, an electrocardiogram, and an echocardiogram. Genetic analyses of the PSEN1, PSEN2, APP, and APOE genes were carried out in patients with AD. They observed a higher prevalence of low-voltage electrocardiographic QRS complexes (28% vs 3%, respectively), a lower voltage/mass ratio, a greater echocardiographic interventricular septum, a greater maximum wall thickness, and a twofold higher prevalence of diastolic dysfunction (70% vs 35%, respectively) in patients with AD vs controls. Overall, patients with AD were found to have electrocardiographic and echocardiographic abnormalities, including diastolic dysfunction. These studies reproduced the pattern of cardiac amyloidosis. The presence of subclinical cardiac involvement, likely associated with Aβ amyloid deposition, in AD was suggested.