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Cancer-related pain: A longitudinal study of time to stable pain control and its clinicodemographic predictors

Journal of Pain and Symptom Management Sep 10, 2019

Reis-Pina P, et al. - Researchers sought to determine the time to stable pain control (SPC: pain intensity ≤ 3 and < 3 breakthrough opioid doses over three consecutive days) in patients with cancer pain. Further, they investigated its baseline clinicodemographic predictors in these patients. Among 319 participants, death of 22 was reported before achieving SPC. The median survival time to SPC was 22 days. Most patients with cancer pain achieved SPC. Strong predictors of time to SPC were substance abuse, a neuropathic pain component, soft tissue pain, and current use of adjuvant analgesia. Multivariable analysis suggest that relative to their respective reference categories, female sex, substance abuse, a neuropathic pain component, and use of ≥ 1 adjuvant analgesic each had time ratios (TRs) > 1 (1.03–2.54), whereas soft tissue pain had a TR = 0.71 (0.62–0.82), reflecting longer and shorter time to SPC, respectively. Hence, identification of these factors may assist triage care services based on therapeutic need and guide analgesic interventions.
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