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Can sodium fluorescein cause contrast-induced nephropathy?

Nephrology Dialysis Transplantation Dec 11, 2019

Yun D, et al. - In order to clarify if or not fluorescent angiography (FAG) can cause contrast-induced nephropathy (CIN), researchers performed this investigation in patients recruited from two tertiary hospitals who had FAG and had serum creatinine results within 4 weeks prior to FAG and 3 days following FAG between 2001 and 2017. They removed cases with concurrent iodinated contrast imaging or receiving dialysis. The screening was performed in 979 patients, and 124 patients with acute kidney injury (AKI) were identified following FAG. By CIN criteria and by CIAKI (contrast-induced acute kidney injury) criteria, the incidence rates of CIN were estimated to be 7.3% and 6.4%, respectively, following the removal of 32 patients with clear causes of AKI other than FAG. As per CIN and CIAKI criteria, CIN may be induced by FAG and FAG appeared to be a possible risk factor for end-stage renal disease progression. However, CIN or CIAKI criteria themselves may overestimate AKI and need careful attention to the interpretation of outcomes.
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