Masala G, et al. - Researchers undertook the randomized 2 × 2 factorial Diet, physical Activity and MAmmography trial to assess if a 24-month dietary and/or physical activity (PA) interventions are effective in reducing mammographic breast density (MBD) in postmenopausal women with high baseline MBD. Randomization was performed of healthy postmenopausal women, attending the Florence (Italy) mammographic screening program, ages 50 to 69 years, nonsmokers, with MBD > 50% and no recent hormone therapy, to (i) a dietary intervention focused on plant foods, with a low glycemic load, low in saturated fats and alcohol; (ii) a PA intervention combining daily moderate intensity activities and one weekly supervised session of more strenuous activity; (iii) both interventions; (iv) general recommendations. Outcomes suggest the 24-month dietary or PA intervention as efficacious in reducing MBD in postmenopausal women.