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Cabergoline may act as a radioprotective agent in Cushing's disease

Clinical Endocrinology Nov 15, 2019

Thakkar K, Lila A, Sarathi V, et al. - In this retrospective case records analysis, researchers analyzed the long-term outcome of conventional/conformal fractionated radiotherapy (CRT) and its predictors in Cushing's disease (CD) patients. The sample consisted of 42 individuals with CD who received CRT as a treatment modality and had at least 12 months post RT follow-up. The dosage was 45 Gy over five weeks in 25 fractions. Data reported that at the time of CRT administration the mean age was 23.7 ± 10.7 (range: 12-48) years. After CRT, there were no important predictors of remission of the disease. In the peri-CRT period, the use of cabergoline did not affect initial remission after CRT but was linked to increased recurrence after initial CD remission.
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