Nicholas JA, et al. - Utilizing patient-reported responses from the US National Health and Wellness Survey (NHWS), researchers conducted a retrospective cross-sectional analysis to measure the burden of illness of employed US adults with relapsing-remitting multiple sclerosis (RRMS) and investigate burden by levels of work impairment. Based on demographic and general health features, data from NHWS 2015–2016 were examined from 196 employed RRMS respondents who were matched 1:4 to employed respondents without MS. According to findings, absenteeism and presenteeism levels were 2 and 1.8 times higher in the employed RRMS population than the employed non-MS population, respectively, after propensity score matching. Respondents with RRMS had lower, work productivity, health-related quality of life (HRQoL), and higher healthcare resource utilization than those without MS among the employed people. Given the significant impact of RRMS on work impairment, there is a need to manage individuals on therapies that improve HRQoL, reduce symptoms, and improve their workforce performance.