Bigna JJ, Modiyinji AF, Nansseu JR, et al. - Via performing systematic review and meta-analysis, researchers sought to determine the global burden of HEV infection in pregnancy. Searching PubMed, Embase, Web of Knowledge, and Global Index Medicus, until January 26, 2020, they identified 52 studies (11,663 pregnant women) for inclusion. The seroprevalence was 3.5% in asymptomatic women (most of whom from high endemic areas) and was 49.6% in symptomatic women (data only from HEV high endemic countries). Findings revealed that in high endemic countries, the burden of HEV infection is high among pregnant women, especially among symptomatic women. Further, they indicated an association of HEV in pregnancy with a two- to three-fold rise in intrauterine foetal demise, a three-fold rise in poor intrauterine foetal maturity, and a significant rise in the likelihood of maternal death. This supports the necessity for specific strategies to limit the exposure of pregnant women to HEV infection, particularly in high endemic areas.