Mekuria M, et al. - By performing this institution-based cross-sectional analysis, researchers evaluated the magnitude of breast self-examination (BSE) practice as well as related factors in female secondary school teachers (n = 247) in Gammo Gofa Zone, South Ethiopia. There were 82 respondents in total, of those, 34.3% had ever performed BSE. Among those, BSE had been practiced monthly (regularly) by only 32 (13.4%). The identified significant predictors of BSE practice included being knowledgeable on BSE, ever heard of BSE, being married, having less perceived barrier to BSE, having high perceived confidence and motivation to BSE. Having ever practiced BSE was reported by one in three women, whereas BSE was regularly practiced by about one in seven women. Not knowing how to perform BSE and forgetfulness (for regular practice) were reported as the chief reasons for not practicing BSE. Thus, there is a requirement for integrated work on behavioral change communication and interferences meant to improve knowledge of BSE, and skills about how to perform BSE. Experts recommended Gammo Gofa Zonal health and educational offices to consider the recognized domains of the health belief model (perceived barrier, perceived confidence, and perceived motivation), which may signify the most effective strategies.