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Breast cancer survival following MRI detection in a high‐risk screening program

The Breast Journal Mar 20, 2020

Hollingsworth AB, et al. - The American Cancer Society introduced guidelines for high‐risk screening with MRI in 2007, based on superior sensitivity of MRI over mammography, albeit without proven mortality reduction. As per these guidelines, women meeting one of the following criteria are recommended to undergo annual MRI in addition to annual mammography starting at age 30 years: BRCA gene positivity (or other named syndromes) or untested first-degree relatives of those genetically predisposed patients; lifetime risk of 20%-25% or greater using models that focus on family history; or radiation to the chest wall between the ages of 10 and 30 years. Despite no confirmation in the mortality end point, international data are maturing with improved survival apparent, albeit subject to lead time and length bias. In this observational study of survival, review of 41 consecutive patients was done whose cancers (85.3% invasive) were identified through 2,039 asymptomatic MRI screenings. Disease‐specific survival of 100% was reported with a minimum follow‐up of 5 years and median follow‐up of 10.2 years (range: 5.0‐15.1).

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