Xiao W, et al. - Using the Surveillance, Epidemiology and End Results database, researchers explored the link between molecular subtypes and distant metastatic sites and their prognostic significance. Study participants were 295,213 patients with invasive breast cancer from 2010 to 2014. They classified subtypes into four categories: hormone receptor (HR⁺)/human epidermal growth factor receptor 2 (HER2⁻), HR⁺/HER2⁺, HR⁻/HER2⁺, and triple-negative (HR⁻/HER2⁻). It was noted that both metastatic sites and subtypes affected the overall survival (OS) significantly after metastasis. Findings suggested an association of breast cancer subtypes with different metastatic patterns and confer different prognostic impacts. Molecular subtypes can identify patients who are more at risk for site-specific metastases. Bone metastases (3.28%), followed by lung (1.52%), liver (1.20%), and brain metastasis (0.35%) was the most common distant metastasis.