Leira Y, et al. - Experts assessed if the levels of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in serum were increased in periodontal disease and if there was a relationship to severity of periodontitis. Findings suggested an increase in serum NT-proBNP levels compared to individuals without periodontitis. Furthermore, the greater the degree of periodontal destruction, the higher the levels of NT-proBNP in serum. As per data, the only periodontal parameter significantly associated with elevated concentrations of NT-proBNP in serum was the periodontal inflamed surface area, a measure of periodontal inflammation and disease activity.