Alnæs D, et al. - Individuals with schizophrenia and healthy controls were compared with respect to their brain structural variability. In addition, researchers examined if respective variability is reflected in the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls. In this case-control and polygenic risk analysis of 1,151 patients and 2,010 controls, they noted higher heterogeneity in schizophrenia for cortical thickness and area, cortical and ventricle volumes, and hippocampal subfields. In an independent sample of 12,490 healthy controls from the UK Biobank, they observed a correlation of higher PRS with thinner frontal and temporal cortices and smaller left CA2/3, but it was not correlated with heterogeneity. These findings suggest the possible correlation of increased interindividual differences in brain structure with schizophrenia, and these may reflect clinical heterogeneity, gene-environment interactions, or secondary disease factors.