Botulinum toxin treatment of spasticity targeted to muscle endplates: An international, randomised, evaluator-blinded study comparing two different botulinum toxin injection strategies for the treatment of upper limb spasticity
BMJ Open May 10, 2019
Rekand T, et al. - Researchers ascertained if botulinum neurotoxin (BoNT) injections that target the neuromuscular junction (NMJ) were non-inferior to current injection practices in terms of effectiveness. In this open-label prospective evaluator-blinded study, findings revealed that the proportion of responders at elbow flexors was 72.7% in the current practice group and 56.8% in the NMJ-targeted group in the intention-to-treat population. Comparable outcomes were noted in the per protocol population. Non-inferiority of NMJ-targeted injections could not be determined due to the limited number of participants, though there was no statistical difference between groups.
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries