Bone adaptation in adult women is related to loading dose: A 12‐month randomized controlled trial
Journal of Bone and Mineral Research Apr 03, 2020
Troy KL, et al. - In this randomized controlled trial, researchers intended to determine if there is an association between mechanical strain magnitude and rate and changes to bone in healthy adult women. They analyzed the impacts of a voluntary upper extremity compressive loading task in healthy adult women during a 12‐month prospective period. In total, 102 women aged 21 to 40 years took part in one of two experiments: (i) low (n = 21) and high (n = 24) strain magnitude; or (ii) low (n = 21) and high (n = 20) strain rate. Sixty‐six candidates finished the study and have been included in the 12‐month analysis. Seventy‐seven candidates had some follow‐up data available and were involved in the analyses of interim time points. The authors discovered that the forearm's compressive load was osteogenic, with groups of high and low strain rates having similarly significant increases to the bone mass. They conclude that in healthy adult women, signals related to strain magnitude, rate, and number of loading bouts lead to bone adaptation, but only explain a small amount of variance in bone changes.
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