Hagström H, et al. - Using national registers and Cox regression model, researchers analyzed the role of a high body mass index (BMI) in women of reproductive age and future risk of severe liver disease. Between 1992 and 2015, data on early pregnancy BMI from 1,139,458 Swedish women were obtained. Seven hundred seventy-four women developed a severe liver disease during an average follow-up of 13.8 years. An increased risk of severe liver disease was found in women with BMI between 22.5 and 24.9 kg/m², 25.0 and 29.9 kg/m² and BMI ≥ 30 kg/m² vs women with a low normal BMI (18.5-22.4). The data presented in this work showed a high BMI early in life in Swedish women was a relevant risk factor for the development of severe liver disease later in life. In women with obesity, the risk was dose-dependent and most pronounced. Findings revealed that women with diabetes had an increased risk of severe liver disease regardless of baseline BMI.