Dickerman BA, et al. - In this prospective study, researchers examined men (n=1832) in the Age, Gene/Environment Susceptibility–Reykjavik study, to determine the role of objectively assessed body fat distribution and the risk of clinically relevant prostate cancer. Risk of advanced and fatal disease was found in relation to visceral fat and thigh subcutaneous fat, respectively, among all men. Association of visceral fat with both advanced and fatal disease was evident among men who were leaner based on body mass index (BMI). A higher risk of advanced and fatal disease was observed in relation to BMI and waist circumference. No adiposity measures showed link with total or high-grade disease. Overall, the association of specific fat depots as well as BMI and waist circumference, with the risk of aggressive prostate cancer, was shown in this study.