Xie L, et al. - Researchers examined a total of 12,672 hypertensive patients with estimated glomerular filtration rate (eGFR) at least 60 ml/min per 1.73 m² from the renal sub-study of the China Stroke Primary Prevention Trial (CSPPT), to determine the correlation of BMI and waist circumference with chronic kidney disease (CKD) development. They focused on the development of CKD (primary outcome), defined as a decrease in eGFR of at least 30% and to a level of less than 60 ml/min per 1.73 m² at the exit visit, or end-stage renal disease. They also looked for rapid renal function decline (secondary outcome), defined as an average decline in eGFR of at least 5 ml/min/1.73 m² per year. They observed a significant link between higher BMI and increased risk of CKD development in hypertensive patients with normal kidney function. No link was seen between waist circumference and development of CKD or rapid renal function decline.