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Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis

Journal of Cystic Fibrosis Sep 13, 2017

Tucker MA, et al. - The objective of this study was to evaluate the effect of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF). According to the findings obtained, patients with mild CF showed impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.

Methods

  • For the purpose of this study, a maximal graded exercise test was conducted to determine exercise capacity (VO2 peak) and peak workload in fourteen pediatric patients with mild CF (age 14 ± 3 y, FEV1 93 ± 16 % predicted) and 14 demographically-matched controls.
  • On a separate visit, members performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined utilizing Doppler ultrasound.
  • Retrograde and antegrade components were additionally examined as indices of blood flow regulation.

Results

  • The present study showed that the cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm, P = 0.038).
  • It was noted that an exaggerated oxidative stress response during exercise occurred in patients only (P = 0.004).

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