Etnel JRG, et al. – Researchers conducted a systematic review and meta-analysis to provide a comprehensive overview of reported outcome following bioprosthetic aortic valve replacement and to translate this to age-specific patient outcome projections. Eligible studies included those that reported on clinical outcome following aortic valve replacement with currently available bioprostheses in older patients (mean age: < 55 years) and were published between January 1, 2000, and January 9, 2016. According to findings, pooled early mortality risk was 3.30%, late mortality rate was 2.39%/year, reintervention was 1.82%/year, structural valve deterioration was 1.59%/year, thromboembolism was 0.53%/year, bleeding was 0.22%/year, and endocarditis was recorded as 0.48%/year. They also noted that 20-year pooled actuarial survival was 58.7%, and freedom from reintervention was 29.0%. Overall, there was an evident association of aortic valve replacement with bioprostheses in young adults with high structural valve deterioration and reintervention rates.