Richard EL, McEvoy LK, Cao SY, et al. - This Mendelian randomization study found no evidence that serum uric acid (SUA), creatinine-based estimated glomerular filtration rate, or cystatin C-based estimated glomerular filtration rate have any effect on cognitive performance. A genetically increased albumin to creatinine ratio (ACR) was linked to slower processing speed and visual memory, but the findings need to be confirmed in independent samples.

• There was no link found between a polygenic ACR score and verbal-numeric reasoning.

• There was, however, some evidence of a link between genetically increased ACR and slower reaction time and poor visual memory.

• In analyses using an unweighted polygenic score and in analyses stratified by gender and age category, ACR was no longer significantly associated with visual memory.

• The pleiotropy adjusted values were directionally consistent with the principal analysis, but they overlapped with the null hypothesis.