Huang ZY, et al. - In the present investigation, researchers assessed systemic inflammatory biomarkers in symptomatic knee osteoarthritis (OA) and their association with radiographic and biochemical OA progression. In plasma of 431 knee OA patients from the doxycycline (DOXY) trial at baseline and 18 months, lipopolysaccharide (LPS) binding protein (LBP), soluble Toll-like receptor 4 (sTLR4) and interleukin 6 (IL-6) were measured. Findings suggested an association of plasma LBP and sTLR4 with knee OA progression over 16–18 months. These outcomes further support the role of systemic low-grade inflammation in knee OA progression pathogenesis. The results were not modified by doxycycline treatment.