Sugiura R, Terui H, Shimada-Omori R, et al. - Despite its limitations, this study suggests that because biologics for psoriasis treatment can affect the balance of T- helper cells, close observation is essential to detect unexpected changes in systemic circumstances of psoriasis patients.

• Psoriasis patients who had biologic therapy at a dermatology clinic between June 10, 2010, and January 29, 2020, had their antinuclear antibody (ANA), eosinophil counts, and immunoglobulin E (IgE) levels examined retrospectively.

• For a total of 128 psoriasis patients, a total of 199 biologic therapies were done.

• Patients treated with infliximab had greater incidences of high ANA and high eosinophils than the non-biologic group of 109 psoriasis patients who underwent non-biologic treatment.

• Brodalumab treatment increased eosinophil counts but had no effect on ANA or IgE levels.

• During the usage of risankizumab, there was a considerable increase in elevated IgE levels.

• The most commonly used concomitant systemic treatment was methotrexate, however, it had no effect on ANA, eosinophil counts, or IgE levels.