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Biological variability of estimated GFR and albuminuria in CKD

American Journal of Kidney Diseases Jul 26, 2018

Waikar SS, et al. - Researchers determined short-term within-person variability of estimated glomerular filtration rate (eGFR) or albuminuria in the setting of clinically stable outpatients with chronic kidney disease (N = 50; mean age, 56.8 years; median eGFR, 40 mL/min/1.73 m2; median urinary albumin-creatinine ratio (UACR), 173 mg/g). In this cross-sectional study with multiple collections over less than 4 weeks, relatively low short-term within-person variability in eGFR markers was seen, whereas albuminuria appeared to have high variability, making it difficult to distinguish random variability from meaningful biologic changes.
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