Dunlop BW, et al. - Researchers evaluated the acute and long-term outcomes resulting from sequentially adding cognitive-behavioral therapy or antidepressant medication for adults with nonremitting depression. They provided an additional 12 weeks of combination treatment to previously untreated adults with major depression who were randomly assigned to receive escitalopram, duloxetine, or cognitive-behavioral therapy (CBT) monotherapy and completed 12 weeks of treatment without achieving remission. Outcomes were not identified to be influenced by the order in which CBT and antidepressant medication were sequentially combined. For patients who do not achieve remission with CBT, antidepressant addition seemed to be an effective approach to treating residual symptoms, as is adding CBT after antidepressant monotherapy. Addition of the alternative modality should be considered for patients who do not respond to one treatment modality.