Shah NB, Hersh BL, Kreger A, et al. - In view of the possibility that outcomes in total knee arthroplasty (TKA) periprosthetic joint infection (PJI) following debridement, antibiotic therapy, and implant retention (DAIR) can be improved by using oral antibiotics for an extended time period after DAIR, researchers here compared DAIR failure rates and adverse events between an initial course of intravenous antibiotic therapy and the addition of extended treatment with oral antibiotics. They performed a multicenter observational study including 108 patients who were diagnosed with a TKA PJI and underwent DAIR. Of these, 47% (n = 51) received an extended course of oral antibiotics. For TKA PJI managed with DAIR, superior infection-free survival was observed in correlation to receiving extending therapy with oral antibiotics. No increase in adverse events was noted, confirming its safety. After 1 year, no significant benefit linked with continued antibiotic therapy was noted.