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Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes

European Journal of Immunology Sep 21, 2017

Tohyama M, et al. - This research investigated the role of Bcl-3 as a potentiator of psoriasis-related gene expression in epidermal keratinocytes. Strong signals for Bcl-3 and p50 were disclosed in the nucleus of epidermal keratinocytes from psoriatic skin, through the immunostaining. The IL-22-STAT3-Bcl-3 pathway could be significant in the pathogenesis of psoriasis.
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