Koehler P, et al. - Researchers sought to assess prognostic variables of invasive aspergillosis (IA) in adults. Searching PubMed database for publications since database inception until May 2018, they identified 58 studies from 267 centers reporting 7,320 patients with IA, and 40 different predictors. Kidney (7.4%, 10/136) and liver failure (3.7%, 5/136), ICU admission (3.7%, 5/136), and uncontrolled underlying disease (3.7%, 5/136) in medical history were unfavorable predictors. Prolonged neutropenia (12.5%, 17/136), corticosteroid treatment (8.1%, 11/136), and graft-vs-host disease (3.7%, 5/136) were the negative outcome predictors as per state of immunosuppression. Galactomannan positivity (8.1%, 11/136), Aspergillus terreus infection (2.2%, 3/136), and lack of amphotericin B susceptibility (1.5%, 2/136) were the relevant predictors on the pathogen side. Disseminated disease (5.1%, 7/136) and CNS involvement (2.9%, 4/136) were the IA-specific predictors. Multiple consolidations (2.9%, 4/136), bipulmonary lesions (2.2%, 3/136), and pleural effusion (2.2%, 3/136) on imaging were associated with negative outcome.