Smucny J, et al. - Researchers examined whether, in patients with recent-onset (< 2 years) psychotic disorders (N = 82), functional MRI (fMRI) measures of cognitive control-related brain circuitry collected at baseline could assist in predicting symptomatic response after 1-year. Classification of participants as improvers (> 20% improvement in total score on the Brief Psychiatric Rating Scale [BPRS] at 1-year follow-up compared with baseline) or as nonimprovers was done. analysis revealed that BPRS improvement and improver status could be significantly predicted using cognitive control–associated measures, with 70% positive predictive value, 60% negative predictive value, and 66% accuracy. The fMRI-based measure (proactive control–associated activation in a priori frontoparietal regions of interest) but not the behavioral measure (d′ context) allowed significant prediction of status.