Del Re EC, Stone WS, Bouix S, et al. - Cortical thickness (CT) and surface area (SA) of frontal, temporal, and parietal brain regions were investigated in a large clinical high risk for psychosis (CHR) sample. Cortical brain abnormalities in CHR who convert to psychosis and in the whole CHR sample were explored, and were compared with the healthy controls (HC). Researchers acquired baseline magnetic resonance imaging, clinical, and cognitive data in 92 HC, 130 non-converters, and 22 converters (conversion assessed at 1-year follow-up). CHR sample had significantly reduced CT but not SA compared with HC. They identified two patterns of findings: (1) converters had significantly reduced CT relative to non-converters and controls in the banks of superior temporal sulcus, Heschl’s gyrus, and pars triangularis and (2) in all high-risk individuals, CT in the inferior parietal and supramarginal gyrus, and at trend level in the pars opercularis, fusiform, and middle temporal gyri was significantly decreased compared with HC. Furthermore, decreased CT linked significantly with older age in HC and in non-converters but not in converters.