Leszczyńska J, et al. - Despite being one of the most common chronic diseases in the elderly, the inflammatory mechanisms of chronic rhinosinusitis (CRS) in older people have not been completely studied, so, researchers performed this study with 529 patients, to assess the bacterial flora of the nose as well as paranasal sinuses in patients suffering from CRS over 65 years of age, including comorbidities, earlier performed endoscopic sinus surgery, presence or absence of polyps and the extent of the inflammatory process. They found a difference in the bacterial flora among older vs younger patients with CRS. Proteus spp. and Pseudomonas aeruginosa were more frequently detected in patients over 65 years of age vs younger patients. Relative to the control group, a more frequent occurrence of S. aureus, Escherichia coli, and Citrobacter spp. was noted in older patients with bronchial asthma. The dominance of Staphylococcus aureus and Escherichia coli in relation to multiple sinus surgical procedures was seen in older patients but not in the control group. Based on the findings, experts recommend considering a different therapeutic approach in older patients with CRS.