Koustas E, Sarantis P, Theoharis S, et al. - The data of 68 individuals with colorectal cancer (CRC, one of the most commonly diagnosed malignancies globally) treated from January 1 to December 31, 2016, were investigated in order to examine the role of autophagy as a protective or tumor suppressor mechanism in CRC cell lines and assess its role as a possible biomarker in human tumor samples. Of overall survival and progression-free survival (PFS), Beclin-1 was an independent prognostic factor. Moreover, of PFS, Rab-7 was recognized as an independent prognostic factor. Additionally, in microsatellite stable (MSS) CRC cell lines, various chemotherapeutic drugs like oxaliplatin and irinotecan inhibited autophagy in a comparable way like hydroxychloroquine and 3-methyladenine. Therefore, a combination of other therapies that involve an autophagy inhibitor could be more advantageous in individuals with MSS who develop chemoresistance.