Awwad ST, et al. - In this study, authors estimated the significance of a novel automated detection software in comparison with human operators to examine the presence and depth of stromal demarcation line on optical coherence tomography (OCT) in 25 keratoconus eyes of 25 subjects post corneal cross-linking using the Dresden protocol, at 3 months postoperatively. They noted the mean corneal demarcation line depth, 321.54 ± 47.71, 322.86 ± 45.77, and 309.21 ± 40.98 μm, as calculated by the automated detection software and the human operators, respectively. They found the intraclass correlation coefficients (ICC) for intersoftware repeatability, 1. They suggested that disclosure of the demarcation line by human operators was repeatable and reproducible.