Lumi X, Pajic SP, Sustar M, et al. - In this prospective case series, researchers reported the safety, anatomical and functional outcomes of autologous neurosensory retinal transplant in patients with a refractory large unclosed macular hole. The sample consisted of four patients [2 male and 2 female patients with a median age of 73 (60–81) years] with a large chronic macular hole that underwent vitrectomy and free-flap neurosensory retinal transplantation surgery with silicone oil tamponade. For the closing of large refractory macular holes, an autologous retinal transplantation surgery is a successful technique. The procedure is safe and offers good anatomical outcomes. Visual acuity, microperimetry, and multifocal electroretinography indicate some gradual functional integration of outer regions of the transplants, but no central functional restitution has yet been identified.