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Autoimmune progesterone dermatitis in the adolescent population

Pediatric Dermatology Apr 22, 2021

Aghazadeh N, Chattha AJ, Hartz MF, et al. - In the present study, the researchers sought to examine the clinical presentation, age of onset, associated conditions, treatments attempted, and therapeutic response of autoimmune progesterone dermatitis (APD) in the adolescent population (younger than 20 years of age). The sample consisted of all adolescent and pediatric patients (< 20 years old at onset) with a documented diagnosis of APD. Seventeen adolescent APD patients were involved (mean age at diagnosis: 14.4 ± 2 years, the mean interval of 13.6 ± 11.1 months between symptom onset and diagnosis). A substantial delay in diagnosis is linked to adolescent APD. Urticaria is the most common manifestation. In adolescent APD, exogenous progestin exposure is rare. Symptoms have been controlled with a continuous combined oral contraceptive, gonadotropin‐releasing hormone agonist, and progesterone desensitization. To better identify, diagnose, and treat this underdiagnosed condition in adolescent patients, large, multicenter studies are required.

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