Baldursdóttir TR, Gíslason GK, Björkholm M, et al. - Researchers sought to ascertain if a prior history of autoimmune disease, a well‐described risk factor for MGUS) confers risk for progression of MGUS to multiple myeloma (MM) or lymphoproliferative diseases (LPs), in this population‐based analysis of 19,303 people diagnosed with MGUS in Sweden from 1985 to 2013. Preceding autoimmune diseases were present in 5,612 (29.1%) MGUS cases. According to findings, a decreased risk of progression from MGUS to MM/other LPs was noted in relation to a history of autoimmune disease. The potential underlying reason is that, biologically less chance of undergoing the genetic events that trigger progression is noted in MGUS caused by chronic antigen stimulation. These data may have implications in clinical counselling for cases with MGUS and underlying autoimmune disease.