Li W, Xiao WM, Luo GP, et al. - This study was undertaken to determine if asymmetrical prominent cortical vein sign (APCVS), defined as more and/or large vessels with greater signal loss than those in the opposite hemisphere on susceptibility-weighted imaging (SWI), on SWI may predict early neurological deterioration (END), defined as an increase in the National Institutes of Health Stroke Scale score ≧ 2 points despite standard treatment in the first 72 h following admission, in acute ischemic stroke patients with severe intracranial arterial stenosis or occlusion (SIASO). The authors retrospectively selected 109 acute ischemic stroke patients with SIASO who underwent SWI. According to results, 30 out of the 109 (27.5%) patients developed END. The APCVS may be a valuable neuroimaging marker for predicting END in acute ischemic stroke patients with SIASO, indicating the importance of evaluation of perfusion status.