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Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma

Journal of Asthma Apr 16, 2020

Lee WY, et al. - Among patients enrolled in the Korean Childhood Asthma Study, researchers investigated if the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients experiencing stable asthma. In this study with 441 individuals, ACT, spirometry, blood tests and FeNO were carried out among patients following stabilization of their asthma. The controlled asthma group displayed significantly higher forced expiratory volume in one second (FEV1), forced expiratory flow between 25% and 75% of forced vital capacity and FEV1/forced vital capacity, on spirometry. Likewise, significantly lower FeNO as well as percent-change in FEV1 was seen in the controlled asthma group. The controlled asthma group had significantly lower eosinophil fraction and significantly higher white blood cell count. Findings are suggestive of the usefulness of ACT as part of the routine assessment of asthmatic children, and its use as a complement to current tools such as spirometry and FeNO measurement was advised.

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